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Abstract
Despite advances in our understanding of risk, development, immunologic control, and
treatment options for lung cancer, it remains the leading cause of cancer death. Tobacco
smoking remains the predominant risk factor for lung cancer development. Nontobacco
risk factors include environmental and occupational exposures, chronic lung disease,
lung infections, and lifestyle factors. Because tobacco remains the leading risk factor
for lung cancer, disease prevention is focused on smoking avoidance and cessation.
Other prevention measures include healthy diet choices and maintaining a physically
active lifestyle. Future work should focus on smoking cessation campaigns and better
understanding disease development and treatment strategies in nonsmokers.