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      Pyridoxine effect in type I primary hyperoxaluria is associated with the most common mutant allele.

      1 , , ,
      Kidney international
      Wiley

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          Abstract

          Pyridoxine (VB6) response in type I primary hyperoxaluria (PHI) is variable, with nearly equal numbers of patients showing partial to complete reductions in oxaluria, and resistance. Because high urine oxalate concentrations cause stones and renal injury, reduction in urine oxalate excretion is deemed favorable. Mechanisms of VB6 action on hepatic alanine:glyoxylate aminotransferase (AGT), the deficient enzyme in PHI, and VB6 dose response have not been well-characterized.

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          Author and article information

          Journal
          Kidney Int
          Kidney international
          Wiley
          0085-2538
          0085-2538
          May 2005
          : 67
          : 5
          Affiliations
          [1 ] Mayo Clinic College of Medicine, Mayo Clinic Foundation, Rochester, Minnesota 55905, USA. monico.carla@mayo.edu
          Article
          S0085-2538(15)50647-9
          10.1111/j.1523-1755.2005.00267.x
          15840016
          d0a6b2c4-d74b-430d-ad76-ba6fb9b672e8
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