1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Migraine genetics: Part II.

      1 ,
      Headache
      Wiley
      genetics, genome-wide association study, hemiplegic migraine, migraine

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Migraine clusters in families and is considered to be a strongly heritable disorder. Hemiplegic migraine is a rare subtype of migraine with aura that may occur as a familial or a sporadic condition. Three genes have been identified studying families with familial hemiplegic migraine (FHM). The first FHM gene that was identified is CACNA1A. A second gene, FHM2, has been mapped to chromosome 1 q 21-23. The defect is a new mutation in the α2 subunit of the Na/K pump (ATP1A2). A third gene (FHM3) has been linked to chromosome 2q24. It is due to a missense mutation in gene SCN1A (Gln1489Lys), which encodes an α1 subunit of a neuronal voltage-gated Na+ channel. Genome-wide association studies have identified many non-coding variants associated with common diseases and traits, like migraine. These variants are concentrated in regulatory DNA marked by deoxyribonuclease I hypersensitive sites. A role has been suggested for the two-pore domain potassium channel, TWIK-related spinal cord potassium channel. TWIK-related spinal cord potassium channel is involved in migraine by screening the KCNK18 gene in subjects diagnosed with migraine.

          Related collections

          Author and article information

          Journal
          Headache
          Headache
          Wiley
          1526-4610
          0017-8748
          Sep 2013
          : 53
          : 8
          Affiliations
          [1 ] Department of Neurology, Thomas Jefferson University, Philadelphia, PA, USA.
          Article
          10.1111/head.12169
          23919895
          d0b89712-961a-485d-b9ee-7692460e86ff
          © 2013 Oxford University Press Headache: The Journal of Head and Face Pain © 2013 American Headache Society.
          History

          genetics,genome-wide association study,hemiplegic migraine,migraine

          Comments

          Comment on this article