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      Novel therapeutic applications of cardiac glycosides.

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          Abstract

          Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit Na+/K+-ATPase. Members of this family have been in clinical use for many years for the treatment of heart failure and atrial arrhythmia, and the mechanism of their positive inotropic effect is well characterized. Exciting recent findings have suggested additional signalling modes of action of Na+/K+-ATPase, implicating cardiac glycosides in the regulation of several important cellular processes and highlighting potential new therapeutic roles for these compounds in various diseases. Perhaps most notably, the increased susceptibility of cancer cells to these compounds supports their potential use as cancer therapies, and the first generation of glycoside-based anticancer drugs are currently in clinical trials.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Science and Business Media LLC
          1474-1784
          1474-1776
          Nov 2008
          : 7
          : 11
          Affiliations
          [1 ] Department of Laboratory Medicine and Pathobiology, University of Toronto, Banting Institute, 100 College Street, Room 110, Toronto, Ontario M5G1L5, Canada.
          Article
          nrd2682
          10.1038/nrd2682
          18948999
          d0c3d5dc-6ece-4d62-b0e6-cc2db4019cce
          History

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