Wire-localized breast biopsy (WLBB) remains the standard method for the surgical excision
of nonpalpable breast lesions. Because of many of its shortcomings, most important
a high microscopic positive margin rate, alternative approaches have been described,
including radioactive seed localization (RSL). This review highlights the literature
regarding RSL, including safety, the ease of the procedure, billing, and oncologic
Medline and PubMed were searched using the terms "radioactive seed" and "breast."
All peer-reviewed studies were included in this review.
RSL is a promising approach for the resection of nonpalpable breast lesions. It is
a reliable and safe alternative to WLBB. RSL is at least equivalent compared with
WLBB in terms of the ease of the procedure, removing the target lesion, the volume
of breast tissue excised, obtaining negative margins, avoiding a second operative
intervention, and allowing for simultaneous axillary staging.
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