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      Naive CD8(+) but not CD4(+) T cells induce maturation of dendritic cells.

      Journal of Molecular Medicine (Berlin, Germany)
      Animals, Antigens, CD4, analysis, immunology, Antigens, CD8, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Cell Aging, Cell Differentiation, Dendritic Cells, cytology, metabolism, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Ovalbumin, genetics, T-Lymphocytes, Cytotoxic

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          Abstract

          We have shown previously that the generation of tumor-reactive CD8(+) cytotoxic T lymphocytes require qualitatively different signals from CD4(+) and CD8(+) T cells that most likely are provided to dendritic cells (DCs). This raises the question of whether the two T cell subsets are equally able to deliver the initial activation signal to DCs. Using ovalbumin as a model antigen we show that naive CD4(+) T cells cannot activate immature DCs and do not become activated, even though they recognize antigen on immature DCs. In contrast, naive CD8(+) T cells rapidly activate DCs and subsequently start to proliferate. This suggests that CD8(+) T cells contribute to DC activation prior to CD4(+) T cells and implies that CD8(+) T cells can provide help to CD4(+) T cells.

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