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Buthionine sulfoximine has anti-Trypanosoma cruzi activity in a murine model of acute Chagas' disease and enhances the efficacy of nifurtimox.
Rodrigo Munoz, Ulrike Kemmerling, Antonio Morello, M Faúndez, Jorge Ferreira, Jorge Ferreira, Lorena M. Orellana, Gloria Luciani-Torres
2008-04-30
Acute Disease, Animals, Buthionine Sulfoximine, pharmacology, therapeutic use, Chagas Disease, drug therapy, mortality, parasitology, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Mice, Mice, Inbred BALB C, Nifurtimox, Survival Rate, Trypanocidal Agents, Trypanosoma cruzi, drug effects
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Acute Disease, Animals, Buthionine Sulfoximine, pharmacology, therapeutic use, Chagas Disease, drug therapy, mortality, parasitology, Disease Models, Animal, Drug Synergism, Drug Therapy, Combination, Mice, Mice, Inbred BALB C, Nifurtimox, Survival Rate, Trypanocidal Agents, Trypanosoma cruzi, drug effects