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      Activation of the interferon-alpha pathway identifies a subgroup of systemic lupus erythematosus patients with distinct serologic features and active disease.

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          Abstract

          Gene-expression studies have demonstrated increased expression of interferon (IFN)-inducible genes (IFIGs) in peripheral blood mononuclear cells (PBMCs) of many patients with systemic lupus erythematosus (SLE), with a predominant effect of type I IFN. This study examined the hypothesis that increased disease severity and activity, as well as distinct autoantibody specificities, characterize SLE patients with activation of the type I IFN pathway.

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          Author and article information

          Journal
          Arthritis Rheum
          Arthritis and rheumatism
          Wiley
          0004-3591
          0004-3591
          May 2005
          : 52
          : 5
          Affiliations
          [1 ] Mary Kirkland Center for Lupus Research, Hospital for Special Surgery and Weill Medical College of Cornell University, New York, New York, USA. kirouk@hss.edu
          Article
          10.1002/art.21031
          15880830
          d0dd3804-afcd-4be5-b288-6d2180bdd0a6
          History

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