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      Elevated levels of circulating DNA and chromatin are independently associated with severe coronary atherosclerosis and a prothrombotic state.

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          Abstract

          Aberrant neutrophil activation occurs during the advanced stages of atherosclerosis. Once primed, neutrophils can undergo apoptosis or release neutrophil extracellular traps. This extracellular DNA exerts potent proinflammatory, prothrombotic, and cytotoxic properties. The goal of this study was to examine the relationships among extracellular DNA formation, coronary atherosclerosis, and the presence of a prothrombotic state.

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          Author and article information

          Journal
          Arterioscler. Thromb. Vasc. Biol.
          Arteriosclerosis, thrombosis, and vascular biology
          1524-4636
          1079-5642
          Aug 2013
          : 33
          : 8
          Affiliations
          [1 ] Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA 02115, USA. Julian.Borissoff@childrens.harvard.edu
          Article
          ATVBAHA.113.301627 NIHMS498733
          10.1161/ATVBAHA.113.301627
          23818485

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