6
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Are platelet indices useful in the evaluation of type 2 diabetic patients? Translated title: Os índices plaquetários são úteis na avaliação de pacientes diabéticos tipo 2?

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          ABSTRACT Introduction: Long-term complications of diabetes mellitus are a leading cause of death in people with diabetes. Recent studies suggest that platelets with altered morphology could be associated with an increased risk for developing vascular complications in diabetes. Objective: To evaluate the platelet parameters in diabetic patients and correlate these indices with microvascular and macrovascular complications of the disease. Materials and methods: We analyzed platelet parameters and biochemical data of patients seen in outpatient clinics of a university hospital. Individuals aged between 30 and 60 years were included, 100 patients with type 2 diabetes mellitus (T2DM) (DM group) and 100 non-diabetic patients (control group). Results: We observed increase in plateletcrit (PCT): 0.21 ± 0.054% vs 0.20 ± 0.045% (p = 0.020); in mean platelet volume (MPV): 8.69 ± 1.288 fl vs 8.27 ± 1.244 fl (p = 0.018); and in platelet distribution width (PDW): 17.8 ± 1.06 fl vs 17.5 ± 0.87 fl (p = 0.039) in the DM and control groups, respectively. Values of MPV, PCT, and PDW were higher among patients with complications of T2DM (p < 0.001). In those with macrovascular disease, we observed a correlation between glycated hemoglobin (A1C) and MPV (p = 0.015) and PDW (p = 0.009) levels. Among patients with microvascular complications, there was a correlation between platelet count and MPV with A1C levels (p < 0.001). Conclusion: The study findings point to significant differences in platelet parameters in patients with T2DM, suggesting the presence of more reactive and aggregatable platelets in this group of individuals. These results suggest that platelet evaluation may be useful in the early detection of long-term complications in diabetic patients, considering that it is a simple and low-cost tool.

          Translated abstract

          RESUMO Introdução: O desenvolvimento das complicações crônicas relacionadas com diabetes mellitus representa a principal causa de mortalidade nesse grupo de indivíduos. Estudos recentes sugerem que plaquetas com morfologia alterada poderiam estar associadas ao aumento do risco de complicações vasculares no diabetes. Objetivo: Avaliar os índices plaquetários em diabéticos, correlacionando-os com as complicações micro e macrovasculares da doença. Materiais e métodos: Foi realizada a análise de índices plaquetários e dados bioquímicos de pacientes atendidos nos ambulatórios de um hospital universitário. Foram incluídos indivíduos com idade entre 30 e 60 anos, sendo 100 diabéticos (grupo DM) e 100 não diabéticos (grupo-controle). Resultados: Observou-se elevação do plaquetócrito: 0,21 ± 0,054% versus 0,20 ± 0,045% (p = 0,020); do volume plaquetário médio (VPM): 8,69 ± 1,288 fl versus 8,27 ± 1,244 fl (p = 0,018); e da distribuição de plaquetas (PDW): 17,8 ± 1,06 fl versus 17,5 ± 0,87 fl (p = 0,039), nos grupos DM e controle, respectivamente. Os valores de VPM, plaquetócrito e PDW apresentaram-se mais elevados entre os indivíduos com complicações do diabetes mellitus tipo 2 (DM2) (p < 0,001). Naqueles com complicações macrovasculares, observou-se correlação entre os níveis de hemoglobina glicada (A1C) e VPM (p = 0,015) e PDW (p = 0,009). Entre os pacientes com complicações microvasculares, observou-se correlação entre a plaquetometria e o VPM com os níveis de A1C (p < 0,001). Conclusão: Os dados do presente estudo apontam para diferenças significativas nos índices plaquetários em pacientes com DM2, sugerindo presença de plaquetas mais reativas e agregáveis nesse grupo de indivíduos. Tais resultados sugerem que a avaliação plaquetária pode ser útil na detecção precoce de complicações crônicas em diabéticos, sobretudo por ser ferramenta de fácil obtenção e baixo custo.

          Related collections

          Most cited references33

          • Record: found
          • Abstract: not found
          • Article: not found

          IDF diabetes Atlas

            Bookmark
            • Record: found
            • Abstract: found
            • Article: not found

            Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications.

            Diabetes mellitus (DM) has been considered as a 'prothrombotic state' with enhanced platelet reactivity. Mean platelet volume (MPV) has been evaluated in DM and correlated with retinopathy. This study was aimed at evaluating platelet indices in diabetic versus non-diabetic patients and assessing their utility as indicators of presence of complications in patients with DM. This study included 75 subjects with DM (50 with one or more microvascular complications) and 50 non-selected patients from the hospital as controls. Anticoagulated blood (ethylene diamine tetracetic acid) was collected and analyzed in an automated blood cell counter for platelet count and indices [MPV, platelet distribution width (PDW) and platelet-large cell ratio]. MPV, PDW and platelet-large cell ratio were all significantly higher in diabetic patients compared to the control subjects (P<0·05 for all). Among the diabetics, PDW was higher in those with complications as compared to those without (P = 0·006). On stepwise discriminant analysis using age, duration of diabetes, platelet count and platelet indices, ∼78·6% of patients with diabetic complications were accurately classified. Interestingly, only two input variables (PDW and MPV) qualified for the final discriminant model. Platelet indices, especially PDW, are different between diabetics and controls as well as between diabetics with and without microvascular complications. Discriminant analysis using PDW and MPV could classify majority of patients with diabetic complications.
              Bookmark
              • Record: found
              • Abstract: not found
              • Article: not found

              Classification and diagnosis of diabetes

                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                jbpml
                Jornal Brasileiro de Patologia e Medicina Laboratorial
                J. Bras. Patol. Med. Lab.
                Sociedade Brasileira de Patologia Clínica, Sociedade Brasileira de Patologia, Sociedade Brasileira de Citopatologia
                1678-4774
                April 2016
                : 52
                : 2
                : 96-102
                Affiliations
                [1 ] Universidade Federal de Juiz de Fora Brazil
                Article
                S1676-24442016000200096
                10.5935/1676-2444.20160017
                d0f1ceaf-af16-40b1-93f1-227170adeb8f

                This work is licensed under a Creative Commons Attribution 4.0 International License.

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=1676-2444&lng=en
                Categories
                MEDICAL LABORATORY TECHNOLOGY
                MEDICINE, RESEARCH & EXPERIMENTAL
                PATHOLOGY

                Pathology,Medicine,Clinical chemistry
                hiperglicemia,plaquetas,platelets,diabetes mellitus,hyperglycemia,mean platelet volume,volume plaquetário médio

                Comments

                Comment on this article