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The influence of age on the response of major depression to electroconvulsive therapy: a C.O.R.E. Report.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry

Remission Induction, Age Factors, Aged, Depressive Disorder, Major, therapy, Electroconvulsive Therapy, methods, Female, Humans, Male, Middle Aged

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      As part of a C.O.R.E., multi-site longitudinal study comparing continuation electroconvulsive therapy (ECT) vs. continuation pharmacotherapy, the authors determined the response of 253 patients with major depression to acute-phase, bilateral ECT by use of the 24-item Hamilton Rating Scale for Depression. Remission rates for three age-groups, > or =65 years; 46-64 years; and < or =45 years, were 90 percent, 89.8 percent, and 70 percent, respectively. Age, as a continuous variable, positively influenced response to treatment. Bilateral, dose-titrated ECT is a highly effective acute treatment for major depression, and older age confers a greater likelihood of achieving remission.

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