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      Sexual behavior decreases pain sensitivity and stimulates endogenous opioids in male rats

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      European Journal of Pharmacology

      Elsevier BV

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          Abstract

          In male rats copulation has antinociceptive effects as measured either by shock-induced vocalizations or hindlimb withdrawal to pinch. Prolonged mating reduces the content of endogenous opioids in midbrain but not in hypothalamus or caudate nucleus. Blockage of opiate receptors with the narcotic antagonist naloxone (4 mg/kg) significantly extends the postejaculatory interval. The results indicate that mating is a biological stimulus for the release of endogenous opoids, possibly to (a) prevent intense sexual stimulation from becoming aversive, and (b) increase its reward value.

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          Author and article information

          Journal
          European Journal of Pharmacology
          European Journal of Pharmacology
          Elsevier BV
          00142999
          March 1981
          March 1981
          : 70
          : 3
          : 279-285
          Article
          10.1016/0014-2999(81)90161-8
          6262094
          © 1981

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