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      Nitrate, nitrite and N-nitroso compounds

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          DNA deaminating ability and genotoxicity of nitric oxide and its progenitors.

          Nitric oxide (NO), a multifaceted bioregulatory agent and an environmental pollutant, can also cause genomic alterations. In vitro, NO deaminated deoxynucleosides, deoxynucleotides, and intact DNA at physiological pH. That similar DNA damage can also occur in vivo was tested by treating Salmonella typhimurium strain TA1535 with three NO-releasing compounds, including nitroglycerin. All proved mutagenic. Observed DNA sequence changes were greater than 99% C----T transitions in the hisG46 (CCC) target codon, consistent with a cytosine-deamination mechanism. Because exposure to endogenously and exogenously produced NO is extensive, this mechanism may contribute to the incidence of deamination-related genetic disease and cancer.
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            Vegetables, fruit, and cancer. I. Epidemiology

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              Vegetables, fruit, and cancer. II. Mechanisms

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                Author and article information

                Journal
                European Journal of Pharmacology: Environmental Toxicology and Pharmacology
                European Journal of Pharmacology: Environmental Toxicology and Pharmacology
                Elsevier BV
                09266917
                November 1994
                November 1994
                : 292
                : 1
                : 1-38
                Article
                10.1016/0926-6917(94)90022-1
                d115323b-917d-4c18-a2b2-6775cab2c0f8
                © 1994

                http://www.elsevier.com/tdm/userlicense/1.0/

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