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      Collapsin: A protein in brain that induces the collapse and paralysis of neuronal growth cones

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      Cell
      Elsevier BV

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          Abstract

          Repulsive guidance cues can steer neuronal growth cones during development and prevent mature axons from regenerating. We have identified a 100 kd glycoprotein in the chick brain that is a good candidate for a repulsive cue. Since it induces the collapse and paralysis of neuronal growth cones in vitro, we have named it collapsin. It is effective at concentrations of approximately 10 pM. The C-terminal half of collapsin contains a single immunoglobulin-like domain and an additional highly basic region. The N-terminal half of collapsin shares significant homology with fasciclin IV, a growth cone guidance protein in grasshopper. Recombinant collapsin causes sensory ganglion growth cones to collapse but not retinal ganglion cell growth cones. We propose that collapsin could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          October 1993
          October 1993
          : 75
          : 2
          : 217-227
          Article
          10.1016/0092-8674(93)80064-L
          8402908
          d12934ee-4221-416e-9bad-1bc3ba258af7
          © 1993

          http://www.elsevier.com/tdm/userlicense/1.0/

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