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      Efficacy of paracetamol for acute low-back pain: a double-blind, randomised controlled trial.

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          Abstract

          Regular paracetamol is the recommended first-line analgesic for acute low-back pain; however, no high-quality evidence supports this recommendation. We aimed to assess the efficacy of paracetamol taken regularly or as-needed to improve time to recovery from pain, compared with placebo, in patients with low-back pain.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          1474-547X
          0140-6736
          Nov 1 2014
          : 384
          : 9954
          Affiliations
          [1 ] The George Institute for Global Health, Sydney Medical School, University of Sydney, Camperdown, NSW, Australia; Hunter Medical Research Institute and School of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia. Electronic address: cwilliams@georgeinstitute.org.au.
          [2 ] The George Institute for Global Health, Sydney Medical School, University of Sydney, Camperdown, NSW, Australia.
          [3 ] Faculty of Pharmacy and Centre for Education and Research in Ageing, University of Sydney, Sydney, NSW, Australia.
          [4 ] Faculty of Human Sciences, Macquarie University, Sydney, NSW, Australia.
          [5 ] Clinical Pharmacology, University of New South Wales and St Vincent's Hospital, Darlinghurst, NSW, Australia.
          Article
          S0140-6736(14)60805-9
          10.1016/S0140-6736(14)60805-9
          25064594
          Copyright © 2014 Elsevier Ltd. All rights reserved.

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