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      The effects of histamine, pyrilamine, cimetidine, and ranitidine on secretion of lingual lipase and amylase from rat von Ebner's glands

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          Abstract

          Minced von Ebner's glands of rat tongue were incubated in vitro with histamine and histamine receptor antagonists. At various time intervals, media and homogenates of the tissue were assayed for lingual lipase and amylase activity and percentage secretion calculated. Histamine elicited moderate secretion (≈10%) of lingual lipase and amylase. In contrast, pyrilamine, and H 1 receptor antagonist, elicited>60% secretion. There were statistically significant differences between the percentage secretion of lingual lipase and amylase for basal secretion, as well as for histmine-and pyrilamine-evoked secretion of lingual lipase and amylase for basal secretion, as well as for histamine-and pyrilamine-evoked secretion above basal. The H 2 receptor inhibitors, cimetidine and ranitidine, stimulated secretion of only amylase, but not lingual lipase. When combined with histamine, these antagonists partially inhibited only the secretion of histamine-evoked lingual lipase, but not amylase. The differences in percentage secretion between the two enzymes indicate that exocytosis may not be the only process involved in protein secretion. The anomalous effects of the H 1 and H 2 receptor antagonists necessitate a more detailed characterization of the receptors of von Ebner's glands.

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          Most cited references 34

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          Constitutive and regulated secretion of proteins.

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            Definition and antagonism of histamine H 2 -receptors.

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              Lingual lipase and its role in the digestion of dietary lipid.

              The serous glands of rat tongue were found to contain a potent lipolytic enzyme which hydrolyzed triglyceride to mostly diglyceride and free fatty acids (FFA) at pH 4.5-5.4. Homogenates of lingual serous glands from adult rats hydrolyzed 40-70 mmol of triglyceride/g per h. The soft palate, anterior oral pharyngeal wall, and lateral oral pharyngeal glands also contained the activity, but at a much lower level. The lipolytic activity was also found in saliva collected through an esophageal cannula and in stomach contents of rats fed a fat-rich meal. The stomach contained very little activity, however, when saliva was excluded. Lipolytic activity was not found in the stomach wall or in the parotid, submandibular, and sublingual glands. The findings suggest that the lingual serous glands secrete a lipase which catalyzes in the stomach the conversion of triglyceride to partial glycerides and FFA. It is proposed that this reaction is the first step in the digestion of dietary lipid.
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                Author and article information

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                Birkhäuser-Verlag (Basel )
                0065-4299
                1420-908X
                1992
                : 37
                : 3
                : 210-219
                Affiliations
                [1 ]GRID grid.411667.3, ISNI 0000000121860438, Department of Pediatrics, , Georgetown University Medical Center, ; 3800 Reservoir Road NW, 20007 Washington, DC, USA
                [2 ]GRID grid.413721.2, ISNI 0000 0004 0419 317X, Department of Veterans Affairs Medical Center, , Oral Pathology Research Laboratory (151-I), ; 50 Irving Street NW, 20427 Washington, DC, USA
                [3 ]GRID grid.417587.8, ISNI 0000000122433366, Present Address: Center for Food Safety and Applied Nutrition, Division of Mathematics, , Food and Drug Administration, ; 200 C Street SW, 20204 Washington, DC, USA
                Article
                BF02028111
                10.1007/BF02028111
                7087539
                1284190
                © Birkhäuser Verlag 1992

                This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

                Categories
                Allergy and Histamine
                Custom metadata
                © Birkhäuser Verlag 1992

                lipase, cimetidine, amylase, histamine, receptor antagonist

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