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      Electrotonic Propagation of Kinin-Induced, Endothelium-Dependent Hyperpolarizations in Pig Coronary Smooth Muscles

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          Abstract

          The kinins, substance P and bradykinin, cause endothelium-dependent hyperpolarizations in smooth muscles of the pig coronary artery. We tested whether the propagation, in the media, of these hyperpolarizations is passive or whether the hyperpolarizations are regenerated in the smooth muscle cells. The space constants measured in response to the kinin endothelium-dependent stimulations were compared to those obtained by electrical field stimulation. The space constant is 2.6 ± 0.2 mm (n = 13) measured for substance P and 2.2 ± 0.2 mm (n = 12) for bradykinin. The space constants established by electrical field stimulation-induced hyperpolarization are 3 ± 0.2 mm (n = 7) for strips with intact endothelium and 2.7 ± 0.3 mm (n = 7) for strips with removed endothelium. These results show that the space constants obtained for the kinin stimulations are not larger than those caused by electrical field stimulation. This suggests that the kinin-induced hyperpolarizations propagate, in the media, in a passive, electronic manner, therefore the hypothesis of regenerated kinin hyperpolarizations is unlikely.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1996
          1996
          24 September 2008
          : 33
          : 5
          : 380-385
          Affiliations
          Department of Zoology and Animal Biology, Geneva University, Geneva, Switzerland
          Article
          159166 J Vasc Res 1996;33:380–385
          10.1159/000159166
          8862143
          © 1996 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 6
          Categories
          Research Paper

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