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      Immunologic factors in human milk during the first year of lactation

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      The Journal of Pediatrics

      Elsevier BV

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          Abstract

          The effects of the duration of lactation upon lactoferrin, lysozyme, total IgA, SIgA, SIgA antibodies to Escherichia coli somatic antigens and leukocytes in human milk were investigated. Longitudinal and cross-sectional studies were performed with milk collected from women 20 to 35 years of age during te first year of lactation. Collection and storage conditions and immunologic analyses were controlled to minimize confounding variables. The concentrations of lactoferrin, total IgA, and leukocytes and the uptake of 3H-thymidine by phytohemagglutinin-stimulated lymphocytes fell during the first several weeks of lactation; afterward, the levels of lactoferrin and IgA stabilized. Approximately 90% of total IgA in human milk during the year was SIgA. Secretory IgA antibody titers to E. coli increased in some individuals studied longitudinally suggesting that the enteromammary gland pathway of SIgA antibody production was active after several weeks of lactation. Moreover, the concentrations of lysozyme, after falling to a nadir of 20 to 30 micrograms/ml at 2 to 4 weeks, rose to 200 to 300 micrograms/ml by six months and remained elevated. The immunologic system in human milk undergoes remarkable changes which may represent adaptations for the recipient infant.

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          Most cited references 9

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          Antibody-forming cells in human colostrum after oral immunisation.

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            Host resistance factors in human milk.

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              ANTIMICROBIAL FACTORS IN HUMAN MILK

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                Author and article information

                Journal
                The Journal of Pediatrics
                The Journal of Pediatrics
                Elsevier BV
                00223476
                April 1982
                April 1982
                : 100
                : 4
                : 563-567
                Article
                10.1016/S0022-3476(82)80753-1
                6977634
                © 1982

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