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      Structural dynamics of dendritic spines in memory and cognition

      , , , ,
      Trends in Neurosciences
      Elsevier BV

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          Abstract

          Recent studies show that dendritic spines are dynamic structures. Their rapid creation, destruction and shape-changing are essential for short- and long-term plasticity at excitatory synapses on pyramidal neurons in the cerebral cortex. The onset of long-term potentiation, spine-volume growth and an increase in receptor trafficking are coincident, enabling a 'functional readout' of spine structure that links the age, size, strength and lifetime of a synapse. Spine dynamics are also implicated in long-term memory and cognition: intrinsic fluctuations in volume can explain synapse maintenance over long periods, and rapid, activity-triggered plasticity can relate directly to cognitive processes. Thus, spine dynamics are cellular phenomena with important implications for cognition and memory. Furthermore, impaired spine dynamics can cause psychiatric and neurodevelopmental disorders. Copyright 2010 Elsevier Ltd. All rights reserved.

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          Author and article information

          Journal
          Trends in Neurosciences
          Trends in Neurosciences
          Elsevier BV
          01662236
          March 2010
          March 2010
          : 33
          : 3
          : 121-129
          Article
          10.1016/j.tins.2010.01.001
          20138375
          d1890618-b431-4803-a7e4-571850039cde
          © 2010

          https://www.elsevier.com/tdm/userlicense/1.0/

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