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      Reduced hepatic content of dehydroepiandrosterone sulphotransferase in chronic liver diseases.

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          Abstract

          Dehydroepiandrosterone sulphotransferase (DHEA ST) is the enzyme responsible for sulphation of lithocholic acid and other potentially hepatotoxic steroids. We have previously shown that DHEA ST activity is reduced in cytosol of liver from miscellaneous patients with chronic liver disease. The aim of this study was to investigate the cause of diminished sulphotransferase activity in order to further our understanding of whether a reduction in the ability to sulphate potentially hepatotoxic bile acids might play a role in the aetiology of primary cholestatic liver disease.

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          Author and article information

          Journal
          Liver
          Liver
          0106-9543
          0106-9543
          Feb 2000
          : 20
          : 1
          Affiliations
          [1 ] Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, UK.
          Article
          10726960
          d1a3df0a-c03e-47d5-9860-04065481ba42
          History

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