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      Dendritic cells and the control of immunity.

      1 ,
      Nature
      Springer Science and Business Media LLC

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          Abstract

          B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

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          Author and article information

          Journal
          Nature
          Nature
          Springer Science and Business Media LLC
          0028-0836
          0028-0836
          Mar 19 1998
          : 392
          : 6673
          Affiliations
          [1 ] Baylor Institute for Immunology, Research, Baylor Research Institute, Dallas, Texas 75246, USA.
          Article
          10.1038/32588
          9521319
          d1b0106b-3bf5-4ac6-9bc9-ea863eea6924
          History

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