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      Dendritic cells and the control of immunity.

      Nature

      immunology, T-Lymphocytes, Self Tolerance, physiology, Immunity, Humans, Forecasting, cytology, Dendritic Cells, Cell Movement, Cell Differentiation, B-Lymphocytes, Antigen Presentation, Animals

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          Abstract

          B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis. With knowledge comes the realization that these cells are a powerful tool for manipulating the immune system.

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          Author and article information

          Journal
          9521319
          10.1038/32588

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