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      Eradication of Helicobacter Pylori Infections and GERD: A systematic review and meta-analysis

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          Abstract

          Background/Aims

          This study evaluates the association between the eradication of Helicobacter pylori (H. pylori) and gastroesophageal reflux disease (GERD).

          Materials and Methods

          Relevant studies were identified by conducting literature search in PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP databases. The prevalence rates of gastroesophageal reflux, heartburn, epigastric pain, and nausea were extracted from the identified research articles and were used in meta-analysis of relative risks (RR) to achieve an overall effect size of the relationship between H. pylori eradication and GERD.

          Results

          A total of 19 randomized controlled trials were included in this meta-analysis. The prevalence of gastroesophageal reflux was significantly higher in patients with H. pylori eradication compared with patients without it (RR: 1.54, 95% CI: 1.06–2.24; p=0.02). A subgroup analysis did not identify any significant difference in GERD prevalence in studies conducted outside China (RR: 1.62, 95% CI: 0.98–2.68) or in China (RR: 1.30, 95% CI: 0.76–2.22). There were no significant differences in heartburn (RR: 1.03, 95% CI: 0.88–1.20), epigastric pain (RR: 0.98, 95% CI: 0.13–7.56), or nausea (RR: 0.44, 95% CI: 0.07–2.72) risk between patients with and without H. pylori eradication.

          Conclusion

          Eradication of H. pylori infection is found to be associated with GERD, although regional differences may exist in the prevalence. Well-designed studies especially those with stratification of patients’ basic conditions are needed to seek refined evidence of the association between H. pylori eradication and the GERD.

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          Author and article information

          Journal
          Turk J Gastroenterol
          Turk J Gastroenterol
          TJG
          The Turkish Journal of Gastroenterology
          Turkish Society of Gastroenterology
          1300-4948
          2148-5607
          December 2020
          1 December 2020
          : 31
          : 12
          : 853-859
          Affiliations
          [1 ]Department of Gastroenterology, Heilongjiang Province Hospital, Harbin, China
          [2 ]Department of Medical Statistics, Heilongjiang Province Hospital, Harbin, China
          Author notes
          Corresponding Author: Li-Hua Hu; hulihua_med@ 123456163.com

          The first two authors contributed equally to this work.

          Author information
          https://orcid.org/0000-0001-5279-2589
          https://orcid.org/0000-0001-6992-1682
          Article
          PMC7928256 PMC7928256 7928256 tjg-31-12-853
          10.5152/tjg.2020.19699
          7928256
          33625997
          d1c2650e-43fa-4d79-a45c-eb977334f7f9
          Copyright 2020 by Turkish Society of Gastroenterology
          History
          : 05 September 2019
          : 03 March 2020
          Categories
          Original Article: Gastrointestinal Tract

          eradication,meta-analysis,randomized controlled trial,gastroesophageal reflux disease, Helicobacter pylori

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