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      Altered brain myelin sheath morphology after rewarming in situ.

      Ultrastructural Pathology
      Animals, Biological Markers, metabolism, Brain Injuries, etiology, pathology, Cerebrum, physiopathology, Disease Models, Animal, Hemodynamics, Hypothermia, Induced, adverse effects, Male, Microscopy, Electron, Transmission, Myelin Sheath, ultrastructure, Nerve Growth Factors, Rats, Rats, Wistar, Rewarming, S100 Calcium Binding Protein beta Subunit, S100 Proteins

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          Abstract

          In this study cerebral ultrastructure was examined in an in vivo rat model, after rewarming from profound hypothermia (15-13 degrees C). Animals held at 37 degrees C served as controls. After rewarming, brains were examined by electron microscope. Micrographs were taken randomly, analyzed anonymously, and quantified by morphometry. Serum analysis of the stress marker S-100beta was carried out in identical groups. The most striking findings in rewarmed animals, when compared to controls, were alterations of myelin sheaths (p<.008) and elevated S-100beta (p<.0001). This indicates that cells in the central nervous system are susceptible to injury in an experimental model of accidental hypothermia and rewarming.

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