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      Radiation Degradation of β-Glucan Extracted from Brewer’s Yeast for Enhancing Growth Promotion and Immunostimulant Activities on Broilers

      1 , 2 , 3 , 4 , 5 , 6

      International Journal of Polymer Science

      Hindawi Limited

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          Abstract

          Water-soluble low molecular weight β-glucan (WSLMG) was successfully prepared via γ-irradiation of insoluble β-glucan extracted from brewer’s yeast cell walls. The WSLMG content in an irradiated sample increased as the irradiation dose increased. The WSLMGs with a molecular weight (Mw) of 49, 25, and 11 kDa, obtained at correlative doses of 100, 200, and 300 kGy, respectively, were tested using growth promotion and immune stimulant effects in broilers. Supplementation with 500 ppm WSLMGs not only increased the survival rate (33.3%) and average body weight (40%) but also reduced the feed conversion rate (35.4%) in tested broilers. In addition, WSLMGs enhanced both nonspecific and specific immune components in the blood of supplemented broilers. The WSLMG with Mw ~25 kDa showed the highest effect on the growth performance and immunomodulatory capability in the immune systems of the tested broilers. In conclusion, this product demonstrates substantial promise as an immunostimulant and growth-promoting additive for poultry.

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          (1→3)-β-d-Glucans as biological response modifiers: a review of structure-functional activity relationships

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            Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi).

            Nowadays macrofungi are distinguished as important natural resources of immunomodulating and anticancer agents and with regard to the increase in diseases involving immune dysfunction, cancer, autoimmune conditions in recent years, applying such immunomodulator agents especially with the natural original is vital. These compounds belong mainly to polysaccharides especially beta-d-glucan derivates, glycopeptide/protein complexes (polysaccharide-peptide/protein complexes), proteoglycans, proteins and triterpenoids. Among polysaccharides, beta(1-->3)-d-glucans and their peptide/protein derivates and among proteins, fungal immunomodulatory proteins (Fips) have more important role in immunomodulating and antitumor activities. Immunomodulating and antitumor activity of these metabolites related to their effects to act of immune effecter cells such as hematpoietic stem cells, lymphocytes, macrophages, T cells, dendritic cells (DCs), and natural killer (NK) cells involved in the innate and adaptive immunity, resulting in the production of biologic response modifiers. In this review we have introduced the medicinal mushrooms' metabolites with immunomoduling and antitumor activities according to immunological evidences and then demonstrated their effects on innate and adaptive immunity and also the mechanisms of activation of immune responses and signaling cascade. In addition, their molecular structure and their relation to these activities have been shown. The important instances of these metabolites along with their immunomodulating and/or antitumor activities isolated from putative medicinal mushrooms are also introduced.
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              Fungal β-Glucans and Mammalian Immunity

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                Author and article information

                Journal
                International Journal of Polymer Science
                International Journal of Polymer Science
                Hindawi Limited
                1687-9422
                1687-9430
                January 22 2019
                January 22 2019
                : 2019
                : 1-9
                Affiliations
                [1 ]Nha Trang Vaccines and Biological Products Joint Stock Company, Khanh Hoa, Vietnam
                [2 ]Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam
                [3 ]Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam
                [4 ]Institute of Tropical Biology, Vietnam Academy of Science and Technology, Vietnam
                [5 ]Biotechnology Center of Ho Chi Minh City, 2374, Highway 1, Trung My Tay Ward, District 12, Ho Chi Minh City, Vietnam
                [6 ]Ho Chi Minh University for Natural Resources and Environment, Ho Chi Minh City, Vietnam
                Article
                10.1155/2019/8901824
                © 2019

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