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      MPO-ANCA-Associated Small Vessel Vasculitis Presenting as Fever of Unknown Origin


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          Microscopic polyangiitis (MPA) is an antineutrophil cytoplasmic antibody (ANCA) associated small vessel vasculitis which can present with various clinical manifestations, for which the mainstay of treatment is systemic corticosteroids and immunosuppressants. We report a case of a 54-year-old female admitted to the hospital because of fever during the last month, leukocytosis and elevated erythrocyte sedimentation rate. Persistence of elevated serum creatinine levels and accompanying hematuria led us to perform a renal biopsy, and MPA was diagnosed on the basis of light and immunofluorescence microscopy. Remission was induced with oral corticosteroids and cyclophosphamide therapy in conjunction with plasmapheresis (PF). The objective of this report was to assess the role of PF in the treatment of MPA and report on its utility in patients with MPA who are not responding to standard therapy or who require unacceptably high doses of steroids or immunosuppressants. In a patient presenting with fever of unknown origin, microscopic polyangiitis should also be considered in the differential diagnosis.

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          Author and article information

          S. Karger AG
          September 2002
          26 September 2002
          : 92
          : 3
          : 673-675
          Departments of aNephrology, bImmunology, cHematology-Oncology and dPathology, Adnan Menderes University Medical School, Aydın, Turkey
          64068 Nephron 2002;92:673–675
          © 2002 S. Karger AG, Basel

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          : 15 November 2001
          Page count
          Figures: 2, References: 10, Pages: 3
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/64068
          Self URI (text/html): https://www.karger.com/Article/FullText/64068
          Self URI (journal page): https://www.karger.com/SubjectArea/Nephrology
          Case Report

          Cardiovascular Medicine,Nephrology
          Fever of unknown origin,Small vessel vasculitis,Plasmapheresis,MPO-ANCA,Microscopic polyangiitis


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