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Alterations in PACAP-38-like immunoreactivity in the plasma during ictal and interictal periods of migraine patients.
Bernadett Tuka
1 ,
Zsuzsanna Helyes ,
Adrienn Markovics ,
Teréz Bagoly ,
János Szolcsányi ,
Nikoletta Szabó ,
Eszter Tóth ,
Zsigmond Tamás Kincses ,
László Vécsei ,
János Tajti
Oct 2013
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Abstract
Recent studies on migraineurs and our own animal experiments have revealed that pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) has an important role in activation of the trigeminovascular system. The aim of this study was to determine the PACAP-38-like immunoreactivity (LI) in the plasma of healthy subjects, and parallel with the calcitonin gene-related peptide (CGRP)-LI in migraine patients in the ictal and interictal periods.