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      Prolactin and Thyrotropin Response to Thyrotropin-Releasing Hormone in Premenopausal Women with Fibrocystic Disease of the Breast

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          Abstract

          Plasma PRL, TSH, total and free T<sub>4</sub>, total and free T<sub>3</sub>, and 17β-estradiol were evaluated in 29 premenopausal women with well-documented fibrocystic disease of the breast and in 29 healthy matched controls. Plasma PRL and TSH dynamics after acute TRH injection (200 µg i.v.) were also determined. All hormonal measurements were performed in the follicular phase of the menstrual cycle. Neither patients nor controls showed any thyroid function impairment. Basal plasma levels of the examined hormones were in the normal range in both groups. When considering data pertinent to PRL and TSH secretory patterns after TRH stimulation, no difference was recorded between patients and controls for TSH secretion, evaluated in terms of maximum peak, net (Δ) and percent (Δ%) increase above the baseline level and integrated area of response. On the contrary, the response of PRL was significantly higher in patients than controls (maximum peak at 20min, mean ± SE, 119.9 ± 14.1 vs. 60.8 ± 5.5 ng/ml, p < 0.001; integrated area of response, 5,725 ± 908 vs. 3,243 ± 266 ng/ml/120 min, p < 0.01). The results are compatible with the view that, in most patients with fibrocystic disease of the breast, there are abnormalities in the control of PRL secretion, which lead to enhanced release of the hormone after stimulation. In such cases the control of TSH appears to be operating normally.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          1663-2818
          1663-2826
          1985
          1985
          26 November 2008
          : 21
          : 3
          : 137-144
          Affiliations
          aIstituto di Medicina Interna, Cattedra di Patologica Medica D, and bClinica Chirurgica A, Università degli Studi, Torino, Italia
          Article
          180038 Horm Res 1985;21:137–144
          10.1159/000180038
          3922866
          © 1985 S. Karger AG, Basel

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          Page count
          Pages: 8
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