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      Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.

      Nature reviews. Cancer

      Aneuploidy, Basic-Leucine Zipper Transcription Factors, genetics, physiology, Cell Transformation, Neoplastic, Cell Transformation, Viral, DNA Damage, Gene Products, tax, Human T-lymphotropic virus 1, Humans, Leukemia-Lymphoma, Adult T-Cell, pathology, Mitosis, Models, Biological

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          Abstract

          It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.

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          Journal
          17384582
          10.1038/nrc2111

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