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      Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation.

      1 ,
      Nature reviews. Cancer
      Springer Science and Business Media LLC

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          Abstract

          It has been 30 years since a 'new' leukaemia termed adult T-cell leukaemia (ATL) was described in Japan, and more than 25 years since the isolation of the retrovirus, human T-cell leukaemia virus type 1 (HTLV-1), that causes this disease. We discuss HTLV-1 infectivity and how the HTLV-1 Tax oncoprotein initiates transformation by creating a cellular environment favouring aneuploidy and clastogenic DNA damage. We also explore the contribution of a newly discovered protein and RNA on the HTLV-1 minus strand, HTLV-1 basic leucine zipper factor (HBZ), to the maintenance of virus-induced leukaemia.

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          Author and article information

          Journal
          Nat Rev Cancer
          Nature reviews. Cancer
          Springer Science and Business Media LLC
          1474-175X
          1474-175X
          Apr 2007
          : 7
          : 4
          Affiliations
          [1 ] Laboratory of Virus Immunology, Institute for Virus Research, Kyoto University, Japan.
          Article
          nrc2111
          10.1038/nrc2111
          17384582
          d22f5a4f-0741-4102-838e-91c1b690af22
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