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      Sugammadex in the management of rocuronium-induced anaphylaxis.

      BJA: British Journal of Anaesthesia
      Adult, Anaphylaxis, chemically induced, drug therapy, physiopathology, Androstanols, adverse effects, Female, Hemodynamics, drug effects, Humans, Neuromuscular Nondepolarizing Agents, gamma-Cyclodextrins, therapeutic use

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          Abstract

          Anaphylaxis during anaesthesia is a rare event that in ∼60-70% of cases is secondary to neuromuscular blocking agents. It has been suggested previously that the recent introduction of sugammadex may provide a novel therapeutic approach to the management of rocuronium-induced anaphylaxis. We describe the case of a 33-yr-old female who suffered a severe anaphylactic reaction to rocuronium, presenting with cardiovascular collapse on induction of anaesthesia. After 19 min of traditional management, she was given a bolus of sugammadex 500 mg. This was associated with an improvement in the adverse haemodynamic state. The underlying reasons for this are unclear, but sugammadex may potentially be a useful adjunct in the management of rocuronium-induced anaphylaxis.

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