1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Inflammation in Joint Injury and Post-Traumatic Osteoarthritis

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Inflammation is a variable feature of osteoarthritis (OA), associated with joint symptoms and progression of disease. Signs of inflammation can be observed in joint fluids and tissues from patients with joint injuries at risk for development of post-traumatic osteoarthritis (PTOA). Furthermore, inflammatory mechanisms are hypothesized to contribute to the risk of OA development and progression after injury. Animal models of PTOA have been instrumental in understanding factors and mechanisms involved in chronic progressive cartilage degradation observed after a predisposing injury. Specific aspects of inflammation observed in humans, including cytokine and chemokine production, synovial reaction, cellular infiltration and inflammatory pathway activation, are also observed in models of PTOA. Many of these models are now being utilized to understand the impact of post-injury inflammatory response on PTOA development and progression, including risk of progressive cartilage degeneration and development of chronic symptoms post-injury. As evidenced from these models, a vigorous inflammatory response occurs very early after joint injury but is then sustained at a lower level at the later phases. This early inflammatory response contributes to the development of PTOA features including cartilage erosion and is potentially modifiable, but specific mediators may also play a role in tissue repair. Although the optimal approach and timing of anti-inflammatory interventions after joint injury are yet to be determined, this body of work should provide hope for the future of disease modification tin PTOA.

          Related collections

          Author and article information

          Contributors
          Journal
          9305697
          8786
          Osteoarthritis Cartilage
          Osteoarthr. Cartil.
          Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society
          1063-4584
          1522-9653
          30 September 2015
          November 2015
          01 November 2016
          : 23
          : 11
          : 1825-1834
          Affiliations
          [a ]University of Pennsylvania Perelman School of Medicine, Division of Rheumatology, Philadelphia Pennsylvania
          [b ]Translational Musculoskeletal Research Center, Corporal Michael J. Crescenz Department of Veterans Affairs Medical Center, Philadelphia Pennsylvania
          Author notes
          Corresponding author: Carla R. Scanzello MD, PhD, University of Pennsylvania Perelman School of Medicine, Division of Rheumatology, 3400 Spruce St., 8th floor Penn Tower, Philadelphia, PA 19104, Office (215)823-5800 x5666, Fax (215) 662-4500, cscanz@ 123456upenn.edu
          Article
          PMC4630675 PMC4630675 4630675 nihpa725140
          10.1016/j.joca.2015.08.015
          4630675
          26521728
          Categories
          Article

          Comments

          Comment on this article