Strontium and Barium as Substitutes for Calcium on Electrical and Mechanical Activity in Rat Portal Vein

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Abstract

Sr (above 0.5 mm) and Ba (above 0.25 mm) can maintain spontaneous electrical activity of portal vein in the absence of Ca. This is true also in Na-free solution. An approximately normal pattern of activity with well-defined periods of quiescence is obtained with Sr at lower concentrations than with Ca. Ba causes continuous tetanic spike discharge. Excitation-contraction coupling appears less effective with Sr and Ba than with Ca. These differences can explain the different concentration-effect curves obtained for the three ions with regard to integrated isometric force. The contracture responses of depolarized portal vein induced by Ca, Sr or Ba decreased by 27, 44 and 63 %, respectively, after 30 min in Ca-free solution with 1 mm EGTA. No further decrease occurred after 2 h. The mechanical responses to Sr and Ba appear to be combined effects of liberation of tissue Ca and direct action on the contractile system.

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Author and article information

Journal

Journal ID (publisher-id): JVR

Journal ID (nlm-ta): J Vasc Res

Journal ID (doi): 10.1159/issn.1018-1172

Title: Journal of Vascular Research

Publisher: S. Karger AG

ISSN (Print): 1018-1172

ISSN (Electronic): 1423-0135

Publication date Subscription-year: 1974

Publication date (Print): 1974

Publication date (Electronic): 18 September 2008

Volume: 11

Issue: 5-6

Pages: 245-259

Affiliations

Department of Physiology and Biophysics, University of Lund, Lund

Article

Publisher ID: 158019 Other ID: Blood Vessels 1974;11:245–259

DOI: 10.1159/000158019

SO-VID: d26ca648-b275-4a9e-af6b-dff9c618daf3

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 26 March 1974

Date accepted : 28 June 1974

Page count

Pages: 15

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