Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number.

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Abstract

The borders of Thailand harbour the world's most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): August 4 2004

Volume: 364

Issue: 9432

Affiliations

[1 ] Department of Cellular and Molecular Medicine-Infectious Diseases, St George's Hospital Medical School, London, UK (S Krishna DPhil, K Laing PhD, Rina Patel BSc, A-C Uhlemann MD); Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK (E Ashley MD, R McGready PhD, F Nosten PhD, RN Price MD, NJ White DSc); Shoklo Malaria Research Unit, Mae Sod, Tak Province, Thailand (E Ashley MD, A Brockman BSc, R McGready PhD, F Nosten PhD, L Phaipun); Menzies School of Health Research Charles Darwin University, Darwin, Australia (RN Price MD); Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (S Looareesuwan MD, NJ White DSc).

Article

Mid ID: EMS62039 Publisher Item ID: S0140-6736(04)16767-6

DOI: 10.1016/S0140-6736(04)16767-6

PMC ID: 4337987

PubMed ID: 15288742

SO-VID: d26fd41a-e1ae-4d04-9132-d37d28d83eb7

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