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      Barriers and Facilitators of Self-Management in Older People with Type 1 Diabetes: A Narrative Review Focusing on Cognitive Impairment

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          Abstract

          Over the past decades, life expectancy of people with type 1 diabetes has increased considerably, which brings potential challenges due to the process of aging. Cognitive aging and dementia, as well as reductions in visual acuity, hearing and dexterity, can influence the frequency and quality of daily self-management activities, including medication taking and insulin dosing, glucose self-monitoring, and healthy eating. This can increase the risk for hypo- and hyperglycemic events, which, in turn, may contribute to cognitive decline. Because there is a gap in understanding the barriers and facilitators of self-management in older adults with type 1 diabetes and the relationship to cognitive functioning, the authors 1) review the available literature on cognitive aging and type 1 diabetes, 2) describe what self-management in later adulthood entails and the cognitive functions required for effective self-management behaviors, 3) analyze the interaction between type 1 diabetes, cognition, aging, and self-management behaviors, and 4) describe the barriers and facilitators for self-management throughout the life span and how they may differ for older people. Potential evidence-based practices that could be developed for older adults with type 1 diabetes are discussed. There is need for further studies that clarify the impact of aging on T1D self-management, ultimately to improve diabetes care and quality of life.

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          Most cited references69

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          Biochemistry and molecular cell biology of diabetic complications.

          Diabetes-specific microvascular disease is a leading cause of blindness, renal failure and nerve damage, and diabetes-accelerated atherosclerosis leads to increased risk of myocardial infarction, stroke and limb amputation. Four main molecular mechanisms have been implicated in glucose-mediated vascular damage. All seem to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain. This integrating paradigm provides a new conceptual framework for future research and drug discovery.
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            Cognitive reserve in ageing and Alzheimer's disease.

            The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. Epidemiological studies suggest that lifelong experiences, including educational and occupational attainment, and leisure activities in later life, can increase this reserve. For example, the risk of developing Alzheimer's disease is reduced in individuals with higher educational or occupational attainment. Reserve can conveniently be divided into two types: brain reserve, which refers to differences in the brain structure that may increase tolerance to pathology, and cognitive reserve, which refers to differences between individuals in how tasks are performed that might enable some people to be more resilient to brain changes than others. Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia. Copyright © 2012 Elsevier Ltd. All rights reserved.
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                Author and article information

                Journal
                Diabetes Metab Syndr Obes
                Diabetes Metab Syndr Obes
                dmso
                Diabetes, Metabolic Syndrome and Obesity
                Dove
                1178-7007
                12 June 2024
                2024
                : 17
                : 2403-2417
                Affiliations
                [1 ]Department of Community and Behavioral Health, Elson S. Floyd College of Medicine, Washington State University , Spokane, WA, USA
                [2 ]Programa Terceira Idade (PROTER, Old Age Research Group), Department and Institute of Psychiatry, University of São Paulo School of Medicine , São Paulo, Brazil
                [3 ]Post-Graduate Program in Neurology, Universidade Federal Do Estado Do Rio de Janeiro , Rio de Janeiro, Brazil
                [4 ]Department of Medical Psychology, Amsterdam University Medical Center, Vrije Universiteit , Amsterdam, the Netherlands
                [5 ]Department of Medicine, Upstate Medical University , Syracuse, NY, USA
                [6 ]Department of Medicine, Penn State University College of Medicine , Hershey, PA, USA
                [7 ]Department of Psychiatry, University of Pittsburgh School of Medicine , Pittsburgh, PA, USA
                Author notes
                Correspondence: Eelco van Duinkerken, Amsterdam University Medical Centers, Vrije Universiteit, Department of Medical Psychology , De Boelelaan 1117, Amsterdam, 1081 HV, the Netherlands, Email e.vanduinkerken@amsterdamumc.nl
                [*]

                These authors contributed equally to this work

                Author information
                http://orcid.org/0000-0002-2849-0545
                http://orcid.org/0000-0001-8821-289X
                http://orcid.org/0000-0003-4278-917X
                http://orcid.org/0000-0003-0558-9435
                Article
                410363
                10.2147/DMSO.S410363
                11175657
                38872713
                d289d0ca-61c7-4fd6-820c-8ea6d970a4aa
                © 2024 Fonseca et al.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                : 22 January 2024
                : 30 May 2024
                Page count
                Figures: 3, Tables: 2, References: 69, Pages: 15
                Categories
                Review

                Endocrinology & Diabetes
                type 1 diabetes,self-management,cognition,aging
                Endocrinology & Diabetes
                type 1 diabetes, self-management, cognition, aging

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