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      • Record: found
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      Is Open Access

      Individualized dosing of oral propranolol for treatment of infantile hemangioma: a prospective study

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          Abstract

          Introduction

          infantile hemangioma is the most common benign tumor in infancy. Currently, oral propranolol is the treatment of choice for infantile hemangioma, but there is no consensus when it comes to its recommended dosage for this condition. Hence this study was conducted to find out the appropriate dosage of oral propranolol for treatment of infantile hemangioma.

          Methods

          A prospective study was conducted on 25 patients with infantile hemangioma, who were treated with gradually increasing dose of propranolol starting from a lower dose of 1mg/kg/day.

          Results

          17/22(76%) patients showed regression of the tumor at the dose of 1- 1.5 mg/kg/d. 5/22(24%) patients were unresponsive to the treatment with the lower dose and they did not respond even with the gradually escalated dose of 3-4 mg/kg/day.

          Conclusion

          Propranolol in a lower dose of 1-1.5 mg/kg/day is safe and efficacious in the treatment of infantile hemangioma and the lesions which do not show initial response to the lower dose are unlikely to respond to the higher dose of 3-4 mg/kg/day.

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          A randomized, controlled trial of oral propranolol in infantile hemangioma.

          Christine Léauté-Labrèze, Peter Hoeger, Juliette Mazereeuw-Hautier … (2015)
          Oral propranolol has been used to treat complicated infantile hemangiomas, although data from randomized, controlled trials to inform its use are limited.
          Article 0 comments Cited 188 times – based on 0 reviews     Review now
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            Prospective study of infantile hemangiomas: clinical characteristics predicting complications and treatment.

            C. Garzón, Anne W Lucky, Ilona Frieden … (2006)
            Infantile hemangiomas are the most common tumor of infancy. Risk factors for complications and need for treatment have not been studied previously in a large prospective study. This study aims to identify clinical characteristics associated with complications and the need for therapeutic intervention. We conducted a prospective cohort study at 7 US pediatric dermatology clinics with a consecutive sample of 1058 children, aged < or = 12 years, with infantile hemangiomas enrolled between September 2002 and October 2003. A standardized questionnaire was used to collect data on each patient and each hemangioma, including clinical characteristics, complications, and treatment. Twenty-four percent of patients experienced complications related to their hemangioma(s), and 38% of our patients received some form of treatment during the study period. Hemangiomas that had complications and required treatment were larger and more likely to be located on the face. Segmental hemangiomas were 11 times more likely to experience complications and 8 times more likely to receive treatment than localized hemangiomas, even when controlled for size. Large size, facial location, and/or segmental morphology are the most important predictors of poor short-term outcomes as measured by complication and treatment rates.
            Article 0 comments Cited 89 times – based on 0 reviews     Review now
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              Prospective study of infantile haemangiomas: incidence, clinical characteristics and association with placental anomalies.

              Claudia Ryan-Munden, R Butschek, W Tom … (2014)
              The aetiology and exact incidence of infantile haemangiomas (IHs) are unknown. Prior studies have noted immunohistochemical and biological characteristics shared by IHs and placental tissue.
              Article 0 comments Cited 75 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): Pan Afr Med J
                Journal ID (iso-abbrev): Pan Afr Med J
                Journal ID (publisher-id): PAMJ
                Title: The Pan African Medical Journal
                Publisher: The African Field Epidemiology Network
                ISSN (Electronic): 1937-8688
                Publication date (Electronic): 08 April 2019
                Publication date Collection: 2019
                Volume: 32
                Electronic Location Identifier: 155
                Affiliations
                [1 ]Department of Pediatrics, All India Institute of Medical Sciences, Patna, India
                [2 ]Department of Pediatric Surgery, All India Institute of Medical Sciences, Patna, India
                [3 ]Department of General Surgery, Anugrah Narayan Magadh Medical College, Gaya, India
                [4 ]Department of Pharmacology, Jawahar Lal Nehru Medical College, Bhagalpur, India
                Author notes
                [& ]Corresponding author: Arun Prasad, Department of Pediatrics, All India Institute of Medical Sciences, Patna, India
                Article
                Publisher ID: PAMJ-32-155
                DOI: 10.11604/pamj.2019.32.155.16760
                PMC ID: 6607273
                SO-VID: d28d5494-ec20-429a-9f6f-f76ade3662ce
                Copyright © © Arun Prasad et al.
                License:

                The Pan African Medical Journal - ISSN 1937-8688. This is an Open Access article distributed under the terms of the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Date received : 05 August 2018
                Date accepted : 12 December 2018
                Categories
                Subject: Research

                ScienceOpen disciplines: Medicine
                Keywords: infantile hemangioma,propranolol,dose,side effects
                Data availability:
                ScienceOpen disciplines: Medicine
                Keywords: infantile hemangioma, propranolol, dose, side effects

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