The novel biomarker-based ABC (age, biomarkers, clinical history)-bleeding risk score for patients with atrial fibrillation: a derivation and validation study.

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Abstract

The benefit of oral anticoagulation in atrial fibrillation is based on a balance between reduction in ischaemic stroke and increase in major bleeding. We aimed to develop and validate a new biomarker-based risk score to improve the prognostication of major bleeding in patients with atrial fibrillation.

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Journal

Journal ID (iso-abbrev): Lancet

Title: Lancet (London, England)

Publisher: Elsevier BV

ISSN (Electronic): 1474-547X

ISSN (Print): 0140-6736

Publication date (Electronic): Jun 04 2016

Volume: 387

Issue: 10035

Affiliations

[1 ] Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. Electronic address: Ziad.Hijazi@ucr.uu.se.

[2 ] Department of Medical Sciences, Cardiology, Uppsala University, Uppsala, Sweden; Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

[3 ] Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

[4 ] Duke Clinical Research Institute, Duke Medicine, Durham, NC, USA.

[5 ] Population Health Research Institute, Hamilton, ON, Canada.

[6 ] Thomas Jefferson Medical College and the Heart Center, Wynnewood, PA, USA.

[7 ] Boston University Medical Center, Boston, MA, USA.

[8 ] Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden; Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.

Article

Publisher Item ID: S0140-6736(16)00741-8

DOI: 10.1016/S0140-6736(16)00741-8

PubMed ID: 27056738

SO-VID: d2a44b85-b2a1-43fb-b4f5-a9d33b2daa07

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