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      Ribosomally synthesized and post-translationally modified peptide natural product discovery in the genomic era

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      Current opinion in chemical biology

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          Abstract

          In the past 15 years, the cost of sequencing a genome has plummeted. Consequently, the number of sequenced bacterial genomes has exponentially increased, and methods for natural product discovery have evolved rapidly to take advantage of the wealth of genomic data. This review highlights applications of genome mining software to compare and organize large-scale data sets and methods for identifying unique biosynthetic pathways amongst the thousands of ribosomally synthesized and post-translationally modified peptide (RiPP) gene clusters. We also discuss a small number of the many RiPPs discovered in the years 2014–2016.

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          Author and article information

          Journal
          9811312
          21022
          Curr Opin Chem Biol
          Curr Opin Chem Biol
          Current opinion in chemical biology
          1367-5931
          1879-0402
          17 February 2017
          02 March 2017
          June 2017
          01 June 2018
          : 38
          : 36-44
          Affiliations
          Department of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL, 61822, USA
          Author notes
          Corresponding author: Professor Wilfred A. van der Donk, University of Illinois at Urbana-Champaign, Department of Chemistry and Howard Hughes Medical Institute, Urbana, IL 61822, United States, vddonk@ 123456illinois.edu
          Article
          PMC5474203 PMC5474203 5474203 nihpa852776
          10.1016/j.cbpa.2017.02.005
          5474203
          28260651
          d2aa1fa4-04ce-4815-9ae5-71f9614f67c5
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