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      Increased Reactivity of Isolated Rabbit Saphenous Vein after Treatment with Estrogen and Progesterone

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          Abstract

          The effect of estrogen and progesterone on the reactivity of isolated rabbit saphenous veins to adrenergic stimulation by norepinephrine, methoxamine, phenylephrine, and electrical stimulation and the effect of progesterone on the reactivity to barium ions were studied. 8 days after ovariectomy, a saphenous vein was removed and studied in vitro. After 1 and 4 days of hormone therapy, the contralateral vein was removed and its reactivity was compared with that of the first vein and with that of veins from untreated, sham-operated control animals. The reactivity to adrenergic and nonadrenergic stimulation was increased after 4 days of treatment with progesterone (5 mg/day); treatment for 4 days with estrogen (100 µg/day) increased the reactivity to norepinephrine, electrical stimulation, methoxamine, and phenylephrine. The results with progesterone suggest that the increased adrenergic responsiveness is not related to a mechanism controlling adrenergic transmission in veins.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1979
          1979
          19 September 2008
          : 16
          : 5
          : 252-258
          Affiliations
          Mayo Clinic and Mayo Foundation, Rochester, Minn.
          Article
          158213 Blood Vessels 1979;16:252–258
          10.1159/000158213
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 7
          Categories
          Original Paper

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