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      A Comparative Study of the Relaxing Effect of Nitroprusside and Verapamil on Human Umbilical Vessels

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          Relaxing effects of nitroprusside and verapamil on the resting or K-stimulated tension and <sup>45</sup>Ca uptake in human umbilical vessels were investigated. Both nitroprusside and verapamil reduced the resting and K-stimulated tensions in a dose-dependent manner. Nitroprusside was much more effective than verapamil in reducing resting tension. However, verapamil caused a greater relaxation of the K-induced contraction than nitroprusside. In a Ca<sup>2+</sup>-free medium, K<sup>+</sup> still caused a small and sustained contraction. Nitroprusside abolished the contraction in the Ca<sup>2+</sup>-free medium, which verapamil failed to inhibit. Neither nitroprusside nor verapamil affected the resting <sup>45</sup>Ca uptake measured by a lanthanum method. The K-induced increase in <sup>45</sup>Ca uptake was inhibited by verapamil, but not by nitroprusside. The results suggest that nitroprusside unlike verapamil does not act as a Ca<sup>2+</sup> influx inhibitor resulting in the relaxation of human umbilical vessels.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 18
          : 6
          : 321-329
          Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
          158365 Blood Vessels 1981;18:321–329
          © 1981 S. Karger AG, Basel

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          Pages: 9
          Research Paper


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