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      A Comparative Study of the Relaxing Effect of Nitroprusside and Verapamil on Human Umbilical Vessels

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          Abstract

          Relaxing effects of nitroprusside and verapamil on the resting or K-stimulated tension and <sup>45</sup>Ca uptake in human umbilical vessels were investigated. Both nitroprusside and verapamil reduced the resting and K-stimulated tensions in a dose-dependent manner. Nitroprusside was much more effective than verapamil in reducing resting tension. However, verapamil caused a greater relaxation of the K-induced contraction than nitroprusside. In a Ca<sup>2+</sup>-free medium, K<sup>+</sup> still caused a small and sustained contraction. Nitroprusside abolished the contraction in the Ca<sup>2+</sup>-free medium, which verapamil failed to inhibit. Neither nitroprusside nor verapamil affected the resting <sup>45</sup>Ca uptake measured by a lanthanum method. The K-induced increase in <sup>45</sup>Ca uptake was inhibited by verapamil, but not by nitroprusside. The results suggest that nitroprusside unlike verapamil does not act as a Ca<sup>2+</sup> influx inhibitor resulting in the relaxation of human umbilical vessels.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1981
          1981
          19 September 2008
          : 18
          : 6
          : 321-329
          Affiliations
          Department of Pharmacology, School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
          Article
          158365 Blood Vessels 1981;18:321–329
          10.1159/000158365
          © 1981 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Research Paper

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