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      Niosome: A future of targeted drug delivery systems

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          Abstract

          Over the past several years, treatment of infectious diseases and immunisation has undergone a revolutionary shift. With the advancement of biotechnology and genetic engineering, not only a large number of disease-specific biological have been developed, but also emphasis has been made to effectively deliver these biologicals. Niosomes are vesicles composed of non-ionic surfactants, which are biodegradable, relatively nontoxic, more stable and inexpensive, an alternative to liposomes. This article reviews the current deepening and widening of interest of niosomes in many scientific disciplines and, particularly its application in medicine. This article also presents an overview of the techniques of preparation of niosome, types of niosomes, characterisation and their applications.

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          Studies on a high encapsulation of colchicine by a niosome system.

          Yongmei Hao, Fenglin Zhao, Na Li … (2002)
          To prepare niosomes which have high encapsulation capacity for soluble drugs, starting from Span 60 and cholesterol, an improved method, evaporation-sonication method, was proposed. The corresponding niosomes show a good stability at least 40 days. Colchicine was chosen as a model drug for examining the capsulation capacity of these niosomes. To obtain the highest encapsulation efficiency, several factors including the structure of surfactant, level of lipid, content of drug and cholesterol were investigated and optimized. The inner cause was also discussed. The results indicate that the Span 60 is the most ideal surfactant among four kinds of Span. Furthermore, the release studies of colchicine and 5-fluorouracil (5-FU) in vitro from niosomes exhibited a prolonged release profile as studied over a period of 24 h. The results demonstrated that niosomes prepared in this way not only have high encapsulation capacity but also is expected that side effects of drugs may be reduced. It still suggests that this method may be used extensively in the field of encapsulation soluble drugs.
          Article 0 comments Cited 74 times – based on 0 reviews     Review now
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            Vesicular systems in ocular drug delivery: an overview.

            Indu P Kaur, Alka B Garg, Anil Singla … (2004)
            The main aim of pharmacotherapeutics is the attainment of effective drug concentration at the intended site of action for a sufficient period of time to elicit a response. Poor bioavailability of drugs from ocular dosage form is mainly due to the tear production, non-productive absorption, transient residence time, and impermeability of corneal epithelium. Though the topical and localized application are still an acceptable and preferred way to achieve therapeutic level of drugs used to treat ocular disorders but the primitive ophthalmic solution, suspension, and ointment dosage form are no longer sufficient to combat various ocular diseases. This article reviews the constraints with conventional ocular therapy and explores various novel approaches, in general, to improve ocular bioavailability of the drugs, advantages of vesicular approach over these and the future challenges to render the vesicular system more effective.
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              Characterization of vesicles prepared with various non-ionic surfactants mixed with cholesterol

              Fumio Sugawara, Masahiko Abe, Makoto Yuasa … (2003)
              Article 0 comments Cited 71 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J Adv Pharm Technol Res
                Journal ID (publisher-id): JAPTR
                Title: Journal of Advanced Pharmaceutical Technology & Research
                Publisher: Medknow Publications & Media Pvt Ltd (India )
                ISSN (Print): 2231-4040
                ISSN (Electronic): 0976-2094
                Publication date (Print): Oct-Dec 2010
                Volume: 1
                Issue: 4
                Pages: 374-380
                Affiliations
                [1]Department of Pharmaceutical Technology, Jadavpur University, Kolkata – 700 032, West Bengal, India
                Author notes
                Address for correspondence: Dr. Ketousetuo Kuotsu, Department of Pharmaceutical Technology, Jadavpur University, Kolkata - 700 032, West Bengal, Kolkata, India. E-mail: ketousetuoju@ 123456yahoo.in
                Article
                Publisher ID: JAPTR-1-374
                DOI: 10.4103/0110-5558.76435
                PMC ID: 3255404
                PubMed ID: 22247876
                SO-VID: d2c87882-266c-4f09-99cb-3a732b797fe0
                Copyright © Copyright: © Journal of Advanced Pharmaceutical Technology & Research
                License:

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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                Subject: Review Article

                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: bilayer,drug entrapment,surfactants,lamellar,niosomes
                Data availability:
                ScienceOpen disciplines: Pharmacology & Pharmaceutical medicine
                Keywords: bilayer, drug entrapment, surfactants, lamellar, niosomes

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