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      A novel sesquiterpene quinone from Hainan sponge Dysidea villosa

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      Bioorganic & Medicinal Chemistry Letters

      Elsevier BV

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          Abstract

          A new sesquiterpene quinone, 21-dehydroxybolinaquinone (5), together with two known related analogues, bolinaquinone (6) and dysidine (7), had been isolated from the Hainan sponge Dysidea villosa. The structure of the new compound 5 was elucidated on the basis of detailed analysis of spectroscopic data and by comparison with related model compounds. Compounds 5-7 were evaluated for the inhibitory activity against hPTP1B, a potential drug target for treatment of type-II diabetes and obesity, and cytotoxic activity against Hela cell line. The results showed that dysidine (7) had the strongest hPTP1B inhibitory activity with an IC(50) value of 6.70microM and 6 had significant cytotoxic activity against Hela cell line with an IC(50) value of 5.45microM. New compound 5 showed moderate PTP1B inhibitory activity and cytotoxicity with IC(50) values of 39.50 and 19.45microM, respectively.

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          Author and article information

          Journal
          Bioorganic & Medicinal Chemistry Letters
          Bioorganic & Medicinal Chemistry Letters
          Elsevier BV
          0960894X
          January 2009
          January 2009
          : 19
          : 2
          : 390-392
          Article
          10.1016/j.bmcl.2008.11.068
          19091557
          © 2009

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