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      Antibody cross-reactivities between gangliosides and lipopolysaccharides of Campylobacter jejuni serotypes associated with Guillain-Barré syndrome

      1 , 1 , 1 , 1 , 1

      Journal of Endotoxin Research

      SAGE Publications

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          Most cited references 42

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          A randomized trial comparing intravenous immune globulin and plasma exchange in Guillain-Barré syndrome. Dutch Guillain-Barré Study Group.

          The subacute demyelinating polyneuropathy known as Guillain-Barré syndrome improves more rapidly with plasma exchange than with supportive care alone. We conducted a multicenter trial to determine whether intravenous immune globulin is as effective as the more complicated treatment with plasma exchange. To enter the study, patients had to have had Guillain-Barré syndrome for less than two weeks and had to be unable to walk independently. They were randomly assigned to receive either five plasma exchanges (each of 200 to 250 ml per kilogram of body weight) or five doses of a preparation of intravenous immune globulin (0.4 g per kilogram per day). The predefined outcome measure was improvement at four weeks by at least one grade on a seven-point scale of motor function. After 150 patients had been treated, strength had improved by one grade or more in 34 percent of those treated with plasma exchange, as compared with 53 percent of those treated with immune globulin (difference, 19 percent; 95 percent confidence interval, 3 percent to 34 percent; P = 0.024). The median time to improvement by one grade was 41 days with plasma exchange and 27 days with immune globulin therapy (P = 0.05). The immune globulin group had significantly fewer complications and less need for artificial ventilation. In the acute Guillain-Barré syndrome, treatment with intravenous immune globulin is at least as effective as plasma exchange and may be superior.
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            Plasmapheresis and acute Guillain-Barre syndrome

              (1985)
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              Acute axonal polyneuropathy associated with anti-GM1 antibodies following Campylobacter enteritis.

               N Yuki,  S. Sato,  T Miyatake (1990)
              We report 2 patients with Guillain-Barré syndrome (GBS) following Campylobacter jejuni enteritis. Electrophysiologic studies indicated that the predominant process was axonal degeneration of motor nerves, and clinical recovery was poor. Serum testing by thin-layer chromatography and enzyme-linked immunosorbent assay revealed that the sera from both patients contained high titers of IgG antibody against GM1 ganglioside. These cases may represent a subgroup of GBS as acute axonal polyneuropathy following C jejuni enteritis associated with anti-GM1 antibodies.
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                Author and article information

                Journal
                Journal of Endotoxin Research
                Journal of Endotoxin Research
                SAGE Publications
                0968-0519
                September 03 2016
                December 1995
                September 03 2016
                December 1995
                : 2
                : 6
                : 395-403
                Affiliations
                [1 ]Klinisches Institut für Neurologie, University of Vienna, Vienna, Austria, Department of Microbiology, University College, Galway, Ireland
                Article
                10.1177/096805199600200602
                © 1995

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