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The Cardioprotective Role of N-Acetyl Cysteine Amide in the Prevention of Doxorubicin and Trastuzumab–Mediated Cardiac Dysfunction
Vineet Goyal ,
Hilary Bews ,
David Cheung ,
Sheena Premecz ,
Soma Mandal ,
Bilal Shaikh ,
Ryan Best ,
Rahul Bhindi ,
Rakesh Chaudhary ,
Amir Ravandi ,
James Thliveris ,
Pawan K. Singal ,
Saroj Niraula ,
Davinder S. Jassal
December 2016
December 2016
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Abstract
In the breast cancer setting, anticancer therapies including doxorubicin (DOX) and
trastuzumab (TRZ) are associated with a significantly increased risk of cardiotoxicity.
Despite the increasing support for the role of oxidative stress (OS) in its pathophysiology,
we still do not have an optimal antioxidant for the prevention of DOX + TRZ-mediated
cardiac dysfunction. The objective of this study was to investigate whether the novel
antioxidant N-acetylcysteine amide (NACA) can attenuate DOX + TRZ-induced heart failure
in a murine model.