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      Progress in active compounds effective on ulcerative colitis from Chinese medicines

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          Abstract

          Ulcerative colitis (UC), a chronic inflammatory disease affecting the colon, has a rising incidence worldwide. The known pathogenesis is multifactorial and involves genetic predisposition, epithelial barrier defects, dysregulated immune responses, and environmental factors. Nowadays, the drugs for UC include 5-aminosalicylic acid, steroids, and immunosuppressants. Long-term use of these drugs, however, may cause several side effects, such as hepatic and renal toxicity, drug resistance and allergic reactions. Moreover, the use of traditional Chinese medicine (TCM) in the treatment of UC shows significantly positive effects, low recurrence rate, few side effects and other obvious advantages. This paper summarizes several kinds of active compounds used in the experimental research of anti-UC effects extracted from TCM, mainly including flavonoids, acids, terpenoids, phenols, alkaloids, quinones, and bile acids from some animal medicines. It is found that the anti-UC activities are mainly focused on targeting inflammation or oxidative stress, which is associated with increasing the levels of anti-inflammatory cytokine (IL-4, IL-10, SOD), suppressing the levels of pro-inflammatory cytokines (TNF- α, IL-1 β, IL-6, IL-8, IL-23, NF- κB, NO), reducing the activity of MPO, MDA, IFN- γ, and iNOS. This review may offer valuable reference for UC-related studies on the compounds from natural medicines.

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          Author and article information

          Journal
          CJNM
          Chinese Journal of Natural Medicines
          Elsevier
          1875-5364
          20 February 2019
          : 17
          : 2
          : 81-102
          Affiliations
          1 School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
          2 Experiment Center for Teaching and Learning, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
          Author notes
          *Corresponding author: PU Yi-Qiong, Tel: 86-21-51323068, E-mail: puyiq@ 123456163.com

          ΔThese authors contribute to this work equally.

          These authors have no conflict of interest to declare.

          Article
          S1875-5364(19)30012-3
          10.1016/S1875-5364(19)30012-3
          Copyright © 2019 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
          Funding
          Funded by: National Natural Science Foundation of China
          Award ID: 81303233
          Funded by: Shanghai Committee of Science and Technology
          Award ID: 18401931400
          Funded by: Budget Program of Shanghai University of Traditional Chinese Medicine
          Award ID: 2016YSN22
          The work was supported by National Natural Science Foundation of China (No. 81303233), Shanghai Committee of Science and Technology (No. 18401931400), and Budget Program of Shanghai University of Traditional Chinese Medicine (No. 2016YSN22), and College Student Innovation Program Project of Shanghai University of Traditional Chinese Medicine (SHUTCM).

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