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      Diurnal patterns of blood glucose, serum free fatty acids, insulin, glucagon and growth hormone in normals and juvenile diabetics Translated title: Sch�ma d'�volution de la glyc�mie, des acides gras libres, de l'insuline, du glucagon et de l'hormone de croissance dans le, s�rum, chez des sujets normaux et des diab�tiques juv�niles Translated title: Tagesrhythmen des Blutzuckers und der Serumspiegel der freien Fetts�uren, des Insulins, des Glucagons und des Wachstumshormons bei Normalpersonen und jugendlichen Diabetikern

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      Diabetologia

      Springer Science and Business Media LLC

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          Most cited references 17

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          Growth hormone secretion during sleep.

          Plasma growth hormone (GH), insulin, cortisol, and glucose were measured during sleep on 38 nights in eight young adults. Blood was drawn from an indwelling catheter at 30-min intervals; EEG and electrooculogram were recorded throughout the night. In seven subjects, a plasma GH peak (13-72 mmug/ml) lasting 1.5-3.5 hr appeared with the onset of deep sleep. Smaller GH peaks (6-14 mmug/ml) occasionally appeared during subsequent deep sleep phases. Peak GH secretion was delayed if the onset of sleep was delayed. Subjects who were awakened for 2-3 hr and allowed to return to sleep exhibited another peak of GH secretion (14-46 mmug/ml). Peak GH secretion was not correlated with changes in plasma glucose, insulin, and cortisol. The effects of 6-CNS-active drugs on sleep-related GH secretion were investigated. Imipramine (50 mg) completely abolished GH peaks in two of four subjects, whereas chlorpromazine (30 mg), phenobarbital (97 mg), diphenylhydantoin (90 mg), chlordiazepoxide (20 mg), and isocarboxazid (30 mg) did not inhibit GH peaks. Altered hypothalamic activity associated with initiation of sleep results in a major peak of growth hormone secretion unrelated to hypoglycemia or changes in cortisol and insulin secretion.
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            Immunoassay of insulin with insulin-antibody precipitate

             PJ RANDLE,  CN Hales (1963)
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              Colorimetric micro-determination of free fatty acids in plasma

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                Author and article information

                Journal
                Diabetologia
                Diabetologia
                Springer Science and Business Media LLC
                0012-186X
                1432-0428
                February 1970
                February 1970
                : 6
                : 1
                : 27-33
                Article
                10.1007/BF00425888
                5434734
                © 1970

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