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      Establishment of Demodex canis on canine skin engrafted onto scid-beige mice.

        1 , , ,
      The Journal of parasitology

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          Abstract

          A small animal model of canine demodicosis is described. Normal canine skin was engrafted onto scid (severe combined immunodeficient)-beige mice, which lack functional B and T lymphocytes and have reduced natural killer cell activity. The xenografts were later infected with Demodex canis collected from a dog with demodicosis. At 30-112 days following infection, mites were seen histologically in the canine hair follicles of the engrafted skin. Demodex canis adults, nymphs, larvae, and eggs were present in samples macerated in sodium hydroxide. Mite infestations could not be demonstrated in the mouse skin, nor were mites passed from the infected graft to uninfected skin grafts on in-contact mice. This model may be utilized to assess the efficacy of miticidal treatments, to evaluate the importance of specific components of the immune response, and to study the biology of D. canis.

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          Author and article information

          Journal
          J. Parasitol.
          The Journal of parasitology
          0022-3395
          0022-3395
          Dec 1996
          : 82
          : 6
          Affiliations
          [1 ] Department of pathobiology, Ontario Veterinary College, University of Guelph, Ontario, Canada.
          Article
          10.2307/3284199
          8973399
          d329cd0f-c112-4a26-8aa7-3c66e10d356a
          History

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