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      Increased Amounts of C3a and the Terminal Complement Complex at High Dialysis Blood-Flow: The Relation with Dialysis Efficiency

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          To estimate the influence of blood-flow on complement generation and the relation with dialysis efficacy (KT/V) 10 patients underwent cuprophan hemodialyses for 6 h using low (200 ml/min) or high (400 ml/min) blood-flow (n = 40). Dialysis with high blood-flow compared to low induced a more rapid drop in leukocyte count and a more pronounced leukocyte rebound. Net generation of C3a (μg/min) was also larger at all 15 measuring points during high blood-flow dialysis and there was a significantly larger total generation of C3a (after 3 h p < 0.05, after 6 h p < 0.05) as compared to low blood-flow. Reaching a KT/V of 1.2-1.4 with high blood-flow induced a 40% larger total net generation of C3a and 21 % more of TCC than with low blood-flow. Net generation of TCC (AU/min) was higher during the first and last parts of high blood-flow dialysis compared to low. In conclusion, increased blood-flow in order to increase dialysis efficiency (KT/V 1.2-1.4) results in a larger net infusion of complement products with possible impact on immune response and complement-associated pathophysiological mechanisms.

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          Author and article information

          S. Karger AG
          18 December 2008
          : 72
          : 4
          : 523-529
          aDepartment of Medicine, Division of Nephrology, Karolinska Hospital, Stockholm, bGambro Inc, Lund, cDepartment of Mathematical Statistics, University of Lund, dDepartment of Clinical Immunology and Transfusion Medicine, Uppsala Hospital of the University of Uppsala, Sweden
          188933 Nephron 1996;72:523–529
          © 1996 S. Karger AG, Basel

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          Pages: 7
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