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      Phenotypic differences between mdx black mice and mdx albino mice. Comparison of cytokine levels in the blood.

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          Abstract

          In mdx mice, mutation in the muscle protein dystrophin gene results in the development of chronic degeneration of the muscle tissue. We performed a comparative analysis of blood cytokine levels in mdx mice, classical black mice and mice with additional genetic defect responsible for the manifestations of oculocutaneous albinism. In mdx albino mice, the total pool of cytokines (IL-10, IL-6, IL-5, IL-2, IL-1α, IL-4, IL-17, granulocyte-macrophage growth factor, TNF-α, and IFN-γ) was increased. This increase was not associated with selective release of one of the above cytokines into the blood. The fraction of pro-inflammatory cytokines (IL-6, IL-1α, TNF-α) was increased in the total pool and the percentage of antiinflammatory cytokines (IL-4) was reduced. Changes in cytokine pool probably reflect the differences in the severity of the pathological process in the muscle tissue of both genetic variations of mdx mice.

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          Author and article information

          Journal
          Bull. Exp. Biol. Med.
          Bulletin of experimental biology and medicine
          1573-8221
          0007-4888
          Jul 2013
          : 155
          : 3
          Affiliations
          [1 ] N. I. Pirogov Russian National Research Medical University, Moscow, Russia. stenina_ma@rsmu.ru.
          Article
          24137608
          d34f884d-f7be-44e1-a6a4-5369842d939e
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