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      Effects of Tolbutamide and Glyburide on Glucose and Acetate Incorporation into Aortic Lipids of the Dog

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          Abstract

          The use of oral hypoglycemic agents to treat adult-onset diabetes has been implicated in an increased incidence of cardiovascular mortality. Since it is likely that altered arterial wall metabolism plays an important role in the atherogenic process and in cardiovascular disease, the primary aim of the present study was to investigate the in vitro effects of two oral hypoglycemic agents (tolbutamide and glyburide) on glucose and acetate incorporation into aortic lipids of the dog. Tolbutamide resulted in a significantly increased incorporation of glucose into total lipids, phospholipids and fatty acids of aorta, but had no apparent effect on acetate incorporation into aortic lipids. In contrast, glyburide significantly decreased glucose incorporation into the total lipid, phospholipid and triglyceride fractions. Acetate incorporation into the triglyceride, free cholesterol, fatty acid and cholesterol ester fractions of aorta also was significantly decreased by glyburide. The data indicate that the oral hypoglycemic agents tolbutamide and glyburide can alter glucose and acetate utilization by arterial tissue. These observations on arterial lipid metabolism provide sufficient justification for further studies directed towards characterizing the effects of oral hypoglycemic agents on the various aspects of arterial wall metabolism.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1980
          1980
          19 September 2008
          : 17
          : 4
          : 187-195
          Affiliations
          Department of Physiology and Biophysics, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Ark.
          Article
          158248 Blood Vessels 1980;17:187–195
          10.1159/000158248
          © 1980 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 9
          Categories
          Research Paper

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