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      Preliminary data on a genome search in NIDDM siblings: the NIDDM 1 locus on chromosome 2 is not linked to NIDDM in the Sardinian population

      , , , , ,   , , , , Study Group for the Genetics of Diabetes in Sardinia

      Diabetologia

      Springer Science and Business Media LLC

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          Most cited references 4

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          A comprehensive human linkage map with centimorgan density. Cooperative Human Linkage Center (CHLC).

           F Manion,  G Duyk,  J Quillen (1994)
          In the last few years there have been rapid advances in developing genetic maps for humans, greatly enhancing our ability to localize and identify genes for inherited disorders. Through the collaborative efforts of three large groups generating microsatellite markers and the efforts of the 110 CEPH collaborators, a comprehensive human linkage map is presented here. It consists of 5840 loci, of which 970 are uniquely ordered, covering 4000 centimorgans on the sex-averaged map. Of these loci, 3617 are polymerase chain reaction-formatted short tandem repeat polymorphisms, and another 427 are genes. The map has markers at an average density of 0.7 centimorgan, providing a resource for ready transference to physical maps and achieving one of the first goals of the Human Genome Project--a comprehensive, high-density genetic map.
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            A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2.

            Non-insulin-dependent (type 2) diabetes mellitus (NIDDM) is a common disorder of middle-aged individuals characterized by high blood glucose levels which, if untreated, can cause serious medical complications and lead to early death. Genetic factors play an important role in determining susceptibility to this disorder. However, the number of genes involved, their chromosomal location and the magnitude of their effect on NIDDM susceptibility are unknown. We have screened the human genome for susceptibility genes for NIDDM using non-and quasi-parametric linkage analysis methods in a group of Mexican American affected sib pairs. One marker, D2S125, showed significant evidence of linkage to NIDDM and appears to be a major factor affecting the development of diabetes mellitus in Mexican Americans. We propose that this locus be designated NIDDM1.
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              Mapping NIDDM susceptibility loci in French families: studies with markers in the region of NIDDM1 on chromosome 2q.

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                Author and article information

                Journal
                Diabetologia
                Diabetologia
                Springer Science and Business Media LLC
                0012-186X
                1432-0428
                November 1997
                November 1997
                : 40
                : 11
                : 1366-1367
                Article
                10.1007/s001250050835
                © 1997

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