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      Cefazolin concentrations in bone and synovial fluid.

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          Abstract

          A single intravenous dose of one gram of cefazolin was administered prophylactically to forty-eight patients undergoing total joint replacement. The serum half-life of the antibiotic was 1.8 hours, the same value found in normal volunteers. The mean concentration in bone during surgery was 5.7 micrograms per gram of bone. The mean concentration in synovial fluid during surgery was 24.4 micrograms per milliliter of fluid.

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          Author and article information

          Journal
          J Bone Joint Surg Am
          The Journal of bone and joint surgery. American volume
          0021-9355
          0021-9355
          Apr 1978
          : 60
          : 3
          Article
          649639
          d37d7970-cf65-435b-b5b2-3f248b5ef082
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